Whois & Analysis for aimovig.com

Erenumab (INN; developmental code name AMG-334) is a human monoclonal antibody against the calcitonin gene-related peptide receptor (CGRPR) designed for the prevention of migraine.

Migraine is a primary headache disorder characterized by recurrent headaches that are moderate to severe.

Typically, the headaches affect one half of the head, are pulsating in nature, and last from two to 72 hours.

Associated symptoms may include nausea, vomiting, and sensitivity to light, sound, or smell.

The pain is generally made worse by physical activity.

Up to one-third of people have an aura: typically a short period of visual disturbance which signals that the headache will soon occur.

Occasionally, an aura can occur with little or no headache following it.

Calcitonin receptor-like (CALCRL), also known as the calcitonin receptor-like receptor (CRLR), is a human protein.

The Food and Drug Administration (FDA or USFDA) is a federal agency of the United States Department of Health and Human Services, one of the United States federal executive departments.

The FDA is responsible for protecting and promoting public health through the control and supervision of food safety, tobacco products, dietary supplements, prescription and over-the-counter pharmaceutical drugs (medications), vaccines, biopharmaceuticals, blood transfusions, medical devices, electromagnetic radiation emitting devices (ERED), cosmetics, animal foods & feed and veterinary products.

As of 2017, 3/4th of the FDA budget (approximately $700 million) is funded by the pharmaceutical companies due to the "Prescription drug user fee act".

A channel blocker (CB) or ion channel blocker (ICB) is a type of drug which binds inside the pore of a specific type of ion channel and blocks the flow of ions through it, resulting in an alteration of the electrochemical gradient of the cell membrane of neurons and therefore a change in neurotransmission.

Early work on channel blockers was published by Clay Armstrong to explain the action of tetraethylammonium ions, and other similar ions, on the potassium channel current in the squid giant axon.