Whois & Analysis for lsbio.com

Immunohistochemistry (IHC) refers to the process of selectively imaging antigens (e.g. proteins) in cells of a tissue section by exploiting the principle of antibodies binding specifically to antigens in biological tissues.

IHC takes its name from the roots "immuno", in reference to antibodies used in the procedure, and "histo," meaning tissue (compare to immunocytochemistry).

The procedure was conceptualized and first implemented by Albert Coons in 1941.

An antibody (Ab), also known as an immunoglobulin (Ig), is a large, Y-shaped protein produced mainly by plasma cells that is used by the immune system to neutralize pathogens such as bacteria and viruses.

The antibody recognizes a unique molecule of the harmful agent, called an antigen, via the Fab's variable region.

Each tip of the "Y" of an antibody contains a paratope (analogous to a lock) that is specific for one particular epitope (similarly analogous to a key) on an antigen, allowing these two structures to bind together with precision.

Using this binding mechanism, an antibody can tag a microbe or an infected cell for attack by other parts of the immune system, or can neutralize its target directly (for example, by blocking a part of a microbe that is essential for its invasion and survival).

Depending on the antigen, the binding may impede the biological process causing the disease or may activate macrophages to destroy the foreign substance.

The ability of an antibody to communicate with the other components of the immune system is mediated via its Fc region (located at the base of the "Y"), which contains a conserved glycosylation site involved in these interactions.

The production of antibodies is the main function of the humoral immune system.

The enzyme-linked immunosorbent assay (ELISA) is a test that uses antibodies and color change to identify a substance.

Sensitivity and specificity are statistical measures of the performance of a binary classification test, also known in statistics as classification function:

Biomedical research (or experimental medicine) is in general simply known as medical research.

It is the basic research (also called bench science or bench research), applied research, or translational research conducted to aid and support the development of knowledge in the field of medicine.