Whois & Analysis for taltz.com

Ankylosing spondylitis (AS) is a type of arthritis in which there is long term inflammation of the joints of the spine.

Typically the joints where the spine joins the pelvis are also affected.

Occasionally other joints such as the shoulders or hips are involved.

Eye and bowel problems may also occur.

Back pain is a characteristic symptom of AS, and it often comes and goes.

Stiffness of the affected joints generally worsens over time.

Psoriatic arthritis is a long-term inflammatory arthritis that occurs in people affected by the autoimmune disease psoriasis.

The classic feature of psoriatic arthritis is swelling of entire fingers and toes with a sausage-like appearance.

This often happens in association with changes to the nails such as small depressions in the nail (pitting), thickening of the nails, and detachment of the nail from the nailbed.

Skin changes consistent with psoriasis (e.g., red, scaly, and itchy plaques) frequently occur before the onset of psoriatic arthritis but psoriatic arthritis can precede the rash in 15% of affected individuals.

It is classified as a type of seronegative spondyloarthropathy.

Ixekizumab (trade name Taltz) is an injectable drug for the treatment of autoimmune diseases.

Chemically, it is a humanized monoclonal antibody.

The substance acts by blocking interleukin 17, reducing inflammation.

Psoriasis is a long-lasting autoimmune disease which is characterized by patches of abnormal skin.

These skin patches are typically red, itchy, and scaly.

They may vary in severity from small and localized to complete body coverage.

Injury to the skin can trigger psoriatic skin changes at that spot, which is known as the Koebner phenomenon.

Interleukin 17A (IL-17 or IL-17A), originally identified as a transcript from a rodent T-cell hybridoma by Rouvier et al.

in 1993, is the founding member of a group of cytokines called the IL-17 family.

Known as CTLA8 in rodents, IL-17 shows high homology to viral IL-17 encoded by an open reading frame of the T-lymphotropic rhadinovirus Herpesvirus saimiri.