Whois & Analysis for cellsignal.com

Cell Signaling Technology, Inc. (CST) is a privately held company that develops and produces antibodies, ELISA kits, ChIP kits, proteomic kits, and other related regents used to study the cell signaling pathways that impact human health.

CST maintains an in-house research program, particularly in the area of cancer research, and has published scientific papers in many peer-reviewed journals.

Proteomics is the large-scale study of proteins.

Proteins are vital parts of living organisms, with many functions.

The term proteomics was coined in 1997 in analogy with genomics, the study of the genome.

The word proteome is a portmanteau of protein and genome, and was coined by Marc Wilkins in 1994 while a PhD student at Macquarie University.

Macquarie University also founded the first dedicated proteomics laboratory in 1995 (the Australian Proteome Analysis Facility – APAF).

An antibody (Ab), also known as an immunoglobulin (Ig), is a large, Y-shaped protein produced mainly by plasma cells that is used by the immune system to neutralize pathogens such as bacteria and viruses.

The antibody recognizes a unique molecule of the harmful agent, called an antigen, via the Fab's variable region.

Each tip of the "Y" of an antibody contains a paratope (analogous to a lock) that is specific for one particular epitope (similarly analogous to a key) on an antigen, allowing these two structures to bind together with precision.

Using this binding mechanism, an antibody can tag a microbe or an infected cell for attack by other parts of the immune system, or can neutralize its target directly (for example, by blocking a part of a microbe that is essential for its invasion and survival).

Depending on the antigen, the binding may impede the biological process causing the disease or may activate macrophages to destroy the foreign substance.

The ability of an antibody to communicate with the other components of the immune system is mediated via its Fc region (located at the base of the "Y"), which contains a conserved glycosylation site involved in these interactions.

The production of antibodies is the main function of the humoral immune system.

The viscosity of a fluid is a measure of its resistance to gradual deformation by shear stress or tensile stress.

For liquids, it corresponds to the informal concept of "thickness"; for example, honey has a much higher viscosity than water.

An experiment is a procedure carried out to support, refute, or validate a hypothesis.

Experiments provide insight into cause-and-effect by demonstrating what outcome occurs when a particular factor is manipulated.

Experiments vary greatly in goal and scale, but always rely on repeatable procedure and logical analysis of the results.

There also exists natural experimental studies.