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Cytisine, also known as baptitoxine, cytisinicline, or sophorine, is an alkaloid that occurs naturally in several plant genera, such as Laburnum and Cytisus of the family Fabaceae.

It has been used medically to help with smoking cessation.

Although widely used for smoking cessation in Eastern Europe, cytisine remains relatively unknown beyond it.

However, it has been found effective in several randomized clinical trials, including some in the United States and a large one in New Zealand, and is being investigated in additional trials in the United States (being conducted by Achieve Life Sciences) and a non-inferiority trial in Australia in which it is being compared head-to-head with the smoking cessation aid varenicline (sold in the United States as Chantix).

It has also been used entheogenically via mescalbeans by some Native American groups, historically in the Rio Grande Valley predating even peyote.

Bulgaria, officially the Republic of Bulgaria, is a country in Southeast Europe.

Located west of the Black Sea and south of the Danube river, Bulgaria is bordered by Greece and Turkey to the south, Serbia and North Macedonia to the west, and Romania to the north.

It covers a territory of and is the 16th largest country in Europe.

Sofia is the nation's capital and largest city; other major cities include Burgas, Plovdiv, and Varna.

Smoking cessation, usually called quitting smoking or stopping smoking, is the process of discontinuing tobacco smoking.

Tobacco smoke contains nicotine, which is addictive and can cause dependence.

As a result, nicotine withdrawal often makes the process of quitting difficult.