Whois & Analysis for lantus.com

Insulin glargine, marketed under the names Lantus among others, is a long-acting basal insulin analogue, given once daily to help control the blood sugar level of those with diabetes.

It consists of microcrystals that slowly release insulin, giving a long duration of action of 18 to 26 hours, with a "peakless" profile (according to the insulin glargine package insert).

Pharmacokinetically, it resembles basal insulin secretion of non-diabetic pancreatic beta cells.

Sometimes, in type 2 diabetes and in combination with a short acting sulfonylurea (drugs which stimulate the pancreas to make more insulin), it can offer moderate control of serum glucose levels.

In the absence of endogenous insulin—type 1 diabetes, depleted type 2 (in some cases) or latent autoimmune diabetes of adults in late stage—insulin glargine needs the support of fast acting insulin taken with food to reduce the effect of prandially derived glucose.

The blood sugar concentration or blood glucose level is the amount of glucose (sugar) present in the blood of a human or animal.

The body naturally tightly regulates blood glucose levels as a part of metabolic homeostasis.

Glycated hemoglobin (hemoglobin A1c, HbA1c, A1C, or Hb1c; sometimes also referred to as being Hb1c or HGBA1C) is a form of hemoglobin that is measured primarily to identify the three-month average plasma glucose concentration.

The test is limited to a three-month average because the lifespan of a red blood cell is four months (120 days).

However, since RBCs do not all undergo lysis at the same time, HbA1C is taken as a limited measure of 3 months.

It is formed in a non-enzymatic glycation pathway by hemoglobin's exposure to plasma glucose.

HbA1c is a measure of the beta-N-1-deoxy fructosyl component of hemoglobin.

The origin of the naming derives from Hemoglobin type A being separated on cation exchange chromatography.

The first fraction to separate, probably considered to be pure Hemoglobin A, was designated HbA0, the following fractions were designated HbA1a, HbA1b, and HbA1c, respective of their order of elution.

There have subsequently been many more sub fractions as separation techniques have improved.

Normal levels of glucose produce a normal amount of glycated hemoglobin.

As the average amount of plasma glucose increases, the fraction of glycated hemoglobin increases in a predictable way.